0032/2017 - Fatores associados as interações medicamentosas em idosos internados em hospital de alta complexidade. Factors associated with drug interactions in elderly hospitalized in high complexity hospital.
• Ronara Camila de Souza Groia Veloso - Veloso, Ronara Camila de Souza Groia - Universidade Federal de Minas Gerais, Hospital das Clínicas, Residência Integrada Multiprofissional em Saúde - <rgroia@yahoo.com.br>
• Mariana Martins Gonzaga Nascimento - Nascimento, Mariana Martins Gonzaga - Universidade Federal de Minas Gerais - <marianamgn@yahoo.com.br>
• Soraya Coelho Costa - Costa, Soraya Coelho - Hospital das Clinicas da UFMG, Instituto Jenny de Andrade Faria - <soraya.costa@oi.com.br>
• Tácita Pires de Figueredo - de Figueredo, Tácita Pires - Hospital das Clinicas da UFMG, Residência Integrada Multiprofissional em Saúde - <tacitapf@gmail.com>
Área Temática:
Assistência Farmacêutica
Resumo:
O estudo tem como objetivo determinar a frequência de interações medicamentosas potenciais (IMP) entre idosos hospitalizados e os fatores associados. Trata-se de um estudo transversal realizado em um hospital de ensino. A variável dependente do estudo foi a ocorrência de IMP identificadas utilizando o software DrugReax. Também foram identificados os pacientes que desenvolveram reações adversas a medicamentos (RAM) relacionadas à manifestação clínica de IMP. Realizou-se regressão logística para analisar a associação da ocorrência de IMP e variáveis independentes. No estudo foram incluídos 237 idosos, a prevalência de IMP foi de 87,8 % e de RAM relacionadas às interações foi de 6,8%. Identificou-se associação positiva entre a detecção de IMP (OR 8,6; IC95% 2,5-30,0) e internação por diagnóstico de doença do aparelho circulatório e número de medicamentos superior que 14 (OR 9,8; IC95% 2,8-34,3). O estudo evidenciou uma elevada prevalência de IMP na farmacoterapia dos idosos, mas reduzida prevalência de RAM. Além disso detectou associação positiva entre IMP e internação por diagnóstico de doença do aparelho circulatório e número de medicamentos superior a 14. A identificação de fatores associados às IMP permite direcionar medidas de prevenção para populações mais expostas à ocorrência de eventos adversos.
Palavras-chave:
Interações de medicamentosReação adversaIdosoFarmacoterapia
Abstract:
This study aims to determine the frequency of potential drug-drug interactions (PDI) in elderly hospitalized and associated factors. It is a cross-sectional study in a teaching hospital. The dependent variable was the occurrence of potential drug interactions identified using DrugReax software. Clinical manifestation of PDI related to adverse drug reactions were also identified univariate analysis (chi-square) and multivariate (logistic regression) were performed to analyze the association between occurrence of IMP and independent variables. Overall 237 elderly, the prevalence of IMP was 87.8% and ADR related to interactions was 6.8%. Multivariate analysis showed a positive association between the detection of PDI (OR 8.6, 95% CI 2.5 to 30.0), and hospitalization for diagnosis of disease of the circulatory system and number of medications > 14 (OR 9.8, 95 2.8 to 34.3%). The study showed a high prevalence of PDI among the elderly, but reduced prevalence of ADR. Also found a positive association between PDI and hospitalization for diagnosis of disease of the circulatory system and number of medications >14. The identification of factors associated with PDI allows drive prevention measures to population more exposed to adverse events populations.
Keywords:
Drug InteractionsAdverse Drug ReactionsAgedDrug therapy
Factors associated with drug interactions in elderly hospitalized in high complexity hospital.
Resumo (abstract):
This study aims to determine the frequency of potential drug-drug interactions (PDI) in elderly hospitalized and associated factors. It is a cross-sectional study in a teaching hospital. The dependent variable was the occurrence of potential drug interactions identified using DrugReax software. Clinical manifestation of PDI related to adverse drug reactions were also identified univariate analysis (chi-square) and multivariate (logistic regression) were performed to analyze the association between occurrence of IMP and independent variables. Overall 237 elderly, the prevalence of IMP was 87.8% and ADR related to interactions was 6.8%. Multivariate analysis showed a positive association between the detection of PDI (OR 8.6, 95% CI 2.5 to 30.0), and hospitalization for diagnosis of disease of the circulatory system and number of medications > 14 (OR 9.8, 95 2.8 to 34.3%). The study showed a high prevalence of PDI among the elderly, but reduced prevalence of ADR. Also found a positive association between PDI and hospitalization for diagnosis of disease of the circulatory system and number of medications >14. The identification of factors associated with PDI allows drive prevention measures to population more exposed to adverse events populations.
Palavras-chave (keywords):
Drug InteractionsAdverse Drug ReactionsAgedDrug therapy
Veloso, Ronara Camila de Souza Groia, Reis, A.M.M, Nascimento, Mariana Martins Gonzaga, Costa, Soraya Coelho, de Figueredo, Tácita Pires. Fatores associados as interações medicamentosas em idosos internados em hospital de alta complexidade.. Cien Saude Colet [periódico na internet] (2017/fev). [Citado em 24/12/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/fatores-associados-as-interacoes-medicamentosas-em-idosos-internados-em-hospital-de-alta-complexidade/16078?id=16078&id=16078
