0328/2017 - Potential and clinical relevant drug-drug interactions among elderlynursing homes: A multicentre study in Murcia, Spain. Interações medicamentosas potenciais e clinicamente relevantes em instituições de longa permanência para idosos: Um estudo multicêntrico em Murcia, Espanha.
Este estudo pretende identificar a prevalência de interações medicamentosas potenciais (IMP) em idosos institucionalizados e seus fatores associados. Realizamos um estudo observacional, multicêntrico e transversal, durante o último trimestre de 2010. Selecionamos uma amostra de 275 sujeitos (>65 anos) de 10 instituições para idosos de Murcia (Espanha) mediante amostragem aleatória complexa em duas etapas. As IMP foram identificadas usando a base de dados do College of Pharmacists. Estimamos a prevalência de IMP de relevância clínica e os fatores associados foram analisados com análise de regressão uni e multinível. Identificamos 210 IMP, das quais 120 foram consideradas clinicamente relevantes (57,1%) e afetaram 70 idosos (25,8%). Oito grupos farmacológicos constituíram 70,2% das IMP clinicamente relevantes. A prevalência de IMP esteve associada à multimorbidade (OR = 2,3; IC 95% = 1,4-4,5) e tomar dez ou mais medicamentos diariamente (OR = 9,6; IC95% = 4,8-19,1) e uso de medicamentos anti-inflamatórios (OR = 3,9; IC 95% = 1,4-10,4). Este estudo revela que as IMP clinicamente relevantes são muito comuns em idosos institucionalizados e que os serviços devem melhorar seus processos para reduzir a prevalência deste fenômeno.
Palavras-chave:
Interações medicamentosas potenciais, Idosos, Instituições de longa permanecia para idosos.
Abstract:
This study purposes to determine the prevalence of potential and clinical relevant Drug-Drug-Interactions (pDDIs) in institutionalized older adults and to identify the pertinent factors associated. We conduct an observational, multicenter and cross-sectional study during the last quarter of 2010. We ed a sample of 275 subjects (aged >65 years)10 nursing homes of Murcia (Spain) by a two-stage complex sampling. pDDIs were identified using the College of Pharmacists Database. We only considered pDDIs of clinical relevance, and thereafter the relevant factors were identified through uni-level and multi-level regression analyses. A total of 210 pDDIs were identified, 120 of which were considered clinically relevant (57.1%), affecting a total of 70 elderly (25.8%). Eight pharmacological groups made up 70.2% of the clinically relevant pDDIs. More clinically relevant DDIs were found in people suffering several pathologies (OR=2.3; 95%CI=1.4-4.5), and also in people who take ten or more drugs daily (OR=9.6; 95%CI=4.8-19.1), and people who take anti-inflammatory drugs (OR=3.9; 95%CI=1.4-10.4). This study reveals that clinically relevant pDDIs are very common in institutionalized elderly people, and that caregivers should aim at improving their practice in order to reduce the prevalence of this phenomenon.
Keywords:
Potential Drug Interactions, Elderly, Homes for the Aged
Interações medicamentosas potenciais e clinicamente relevantes em instituições de longa permanência para idosos: Um estudo multicêntrico em Murcia, Espanha.
Resumo (abstract):
This study purposes to determine the prevalence of potential and clinical relevant Drug-Drug-Interactions (pDDIs) in institutionalized older adults and to identify the pertinent factors associated. We conduct an observational, multicenter and cross-sectional study during the last quarter of 2010. We ed a sample of 275 subjects (aged >65 years)10 nursing homes of Murcia (Spain) by a two-stage complex sampling. pDDIs were identified using the College of Pharmacists Database. We only considered pDDIs of clinical relevance, and thereafter the relevant factors were identified through uni-level and multi-level regression analyses. A total of 210 pDDIs were identified, 120 of which were considered clinically relevant (57.1%), affecting a total of 70 elderly (25.8%). Eight pharmacological groups made up 70.2% of the clinically relevant pDDIs. More clinically relevant DDIs were found in people suffering several pathologies (OR=2.3; 95%CI=1.4-4.5), and also in people who take ten or more drugs daily (OR=9.6; 95%CI=4.8-19.1), and people who take anti-inflammatory drugs (OR=3.9; 95%CI=1.4-10.4). This study reveals that clinically relevant pDDIs are very common in institutionalized elderly people, and that caregivers should aim at improving their practice in order to reduce the prevalence of this phenomenon.
Palavras-chave (keywords):
Potential Drug Interactions, Elderly, Homes for the Aged
Navalón, CI, Cánovas, JJG, Gama, Zenewton André da Silva, Ruiz, JFS, Estrada, EAAG, Sánchez, EDLC, Fernández, OH. Potential and clinical relevant drug-drug interactions among elderlynursing homes: A multicentre study in Murcia, Spain.. Cien Saude Colet [periódico na internet] (2017/set). [Citado em 23/12/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/potential-and-clinical-relevant-drugdrug-interactions-among-elderlynursing-homes-a-multicentre-study-in-murcia-spain/16380?id=16380&id=16380
