0142/2023 - EXCESSO DE PESO PRÉ-GESTACIONAL E ÁCIDOS GRAXOS POLI-INSATURADOS NO LEITE HUMANO: MODELO TEÓRICO DE CAUSALIDADE PRE-GESTATIONAL OVERWEIGHT AND POLYUNSATURATED FATTY ACIDS IN HUMAN MILK: THEORETICAL MODEL OF CAUSALITY
Introdução: Inúmeros estudos têm se detido na avaliação da associação entre o excesso de peso pré-gestacional e os ácidos graxos poli-insaturados no leite humano. Todavia, diante da complexidade de fatores de risco potencialmente confundidores, é recomendável a utilização de ferramentas gráficas para identificar possíveis vieses. Objetivo: Propor um modelo teórico de causalidade utilizando o Gráfico Acíclico Direcionado entre o excesso de peso pré-gestacional e os ácidos graxos poli-insaturados no leite humano. Métodos: Foi realizada ampla revisão da literatura para identificar as variáveis com relações causais com a exposição e/ou desfecho. A escolha das variáveis para ajuste seguiu o algoritmo gráfico que compreende seis critérios para a seleção de um conjunto mínimo de variáveis potencialmente confundidoras. Resultados: Condições socioeconômicas, intervalo interpartal, idade materna, padrão de consumo alimentar foram as variáveis que devem ser ajustadas a fim de se estimar o efeito total do excesso de peso pré-gestacional sobre o conteúdo dos ácidos graxos poli-insaturados no leite humano. Conclusão: O conjunto mínimo de variáveis encontrado pelo presente estudo pode ser utilizado na análise de outros estudos que avaliem essa associação.
Abstract:
Introduction: Numerous studies have focused on the evaluation of the association between pre-pregnancy excess weight and polyunsaturated fatty acids in human milk. However, given the complexity of potentially confounding risk factors, the use of graphical tools is recommended to identify possible biases. Objective: To propose a theoretical model of causality using the Directed Acyclic Graph between pre-pregnancy excess weight and polyunsaturated fatty acids in human milk. Methods: An extensive literature review was performed to identify variables with causal relationships with exposure and/or outcome. The choice of variables for adjustment followed the graphic algorithm that comprises six criteria for ing a minimum set of potentially confounding variables. Results: Socioeconomic conditions, interpartum interval, maternal age and food consumption pattern were the variables that should be adjusted in order to estimate the total effect of pre-pregnancy excess weight on the content of polyunsaturated fatty acids in human milk. Conclusion: The minimum set of variables found by the present study can be used in the analysis of other studies that evaluate this association.
PRE-GESTATIONAL OVERWEIGHT AND POLYUNSATURATED FATTY ACIDS IN HUMAN MILK: THEORETICAL MODEL OF CAUSALITY
Resumo (abstract):
Introduction: Numerous studies have focused on the evaluation of the association between pre-pregnancy excess weight and polyunsaturated fatty acids in human milk. However, given the complexity of potentially confounding risk factors, the use of graphical tools is recommended to identify possible biases. Objective: To propose a theoretical model of causality using the Directed Acyclic Graph between pre-pregnancy excess weight and polyunsaturated fatty acids in human milk. Methods: An extensive literature review was performed to identify variables with causal relationships with exposure and/or outcome. The choice of variables for adjustment followed the graphic algorithm that comprises six criteria for ing a minimum set of potentially confounding variables. Results: Socioeconomic conditions, interpartum interval, maternal age and food consumption pattern were the variables that should be adjusted in order to estimate the total effect of pre-pregnancy excess weight on the content of polyunsaturated fatty acids in human milk. Conclusion: The minimum set of variables found by the present study can be used in the analysis of other studies that evaluate this association.
Amaral, Y.N.V, Rocha, D. M., Theme-Filha M.M, Moreira, M. E. L. EXCESSO DE PESO PRÉ-GESTACIONAL E ÁCIDOS GRAXOS POLI-INSATURADOS NO LEITE HUMANO: MODELO TEÓRICO DE CAUSALIDADE. Cien Saude Colet [periódico na internet] (2023/Jun). [Citado em 08/10/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/excesso-de-peso-pregestacional-e-acidos-graxos-poliinsaturados-no-leite-humano-modelo-teorico-de-causalidade/18768?id=18768
