0265/2022 - Naltrexona em baixa dose (LDN): tendência de consumo nas capitais brasileiras e Distrito Federal, 2014 – 2020 Low-dose naltrexone (LDN): consumption trend in Brazilian capitals and the Federal District, 2014 – 2020
Estudo ecológico com objetivo de determinar o consumo de naltrexona em baixa dose (LDN) nas 26 capitais brasileiras e Distrito Federal e acompanhar a tendência entre os anos de 2014 e 2020. A coleta de dados da dispensação de naltrexona manipulada, se deu por meio do Sistema Nacional de Gerenciamento de Produtos Controlados, publicizado em 2020, considerando-se baixa dose prescrições de até 5 mg. O cálculo dos coeficientes de dispensação utilizou as estimativas populacionais do Instituto Brasileiro de Pesquisa Geografia e Estatística. Utilizou-se análise estatística descritiva e de regressão generalizada de Prais-Winsten para a série temporal. As tendências observadas foram classificadas em crescentes, estáveis ou decrescentes, com intervalo de confiança de 95% e nível de significância de 5%. Os resultados demonstraram maiores coeficientes de consumo de LDN nas regiões centro-oeste, sul e sudeste e menores nas norte e nordeste. Observou-se dispensação de LDN crescente em 55,6% das capitais, estacionária em 44,4% e ausência de coeficientes decrescentes. Apesar das evidências limitadas quanto à farmacoterapia LDN e da sua prescrição off-label, os dados demonstram que a prescrição, dispensação e consumo vem crescendo no Brasil, com ênfase nas regiões centro-sul do país.
Palavras-chave:
ANVISA, uso off-label, farmacoepidemiologia, farmacovigilância, uso de medicamentos.
Abstract:
An ecological study aimed to determine the consumption of low-dose naltrexone (LDN) in the 26 Brazilian capitals and the Federal District. In addition, it was following the trend of this consumption between the years 2014 to 2020. The data collection regarding the dispensation of manipulated Naltrexone took place through the National System for the Management of Controlled Products, published in 2020, considering low dose prescriptions of up to 5 mg. The calculation of dispensing coefficients used population estimatesthe Brazilian Institute of Geography and Statistics Research were used. Descriptive statistical analysis and generalized Prais-Winsten regression were used for the time series. The observed trends were classified as increasing, stable or decreasing, with a confidence interval of 95% and a significance level of 5%. The results showed higher LDN consumption coefficients in the central-west, south and southeast regions and lower in the north and northeast. An increasing LDN dispensing was observed in 55.6% of the capitals, stationary in 44.4% and absence of decreasing coefficients. Despite the limited evidence regarding LDN pharmacotherapy and its off-label prescription, these data show that the prescription, the dispensing and the consumption have been growing in Brazil, with emphasis on the central-south regions of the country.
Keywords:
ANVISA, off-label use, pharmacoepidemiology, pharmacovigilance, drug use.
Low-dose naltrexone (LDN): consumption trend in Brazilian capitals and the Federal District, 2014 – 2020
Resumo (abstract):
An ecological study aimed to determine the consumption of low-dose naltrexone (LDN) in the 26 Brazilian capitals and the Federal District. In addition, it was following the trend of this consumption between the years 2014 to 2020. The data collection regarding the dispensation of manipulated Naltrexone took place through the National System for the Management of Controlled Products, published in 2020, considering low dose prescriptions of up to 5 mg. The calculation of dispensing coefficients used population estimatesthe Brazilian Institute of Geography and Statistics Research were used. Descriptive statistical analysis and generalized Prais-Winsten regression were used for the time series. The observed trends were classified as increasing, stable or decreasing, with a confidence interval of 95% and a significance level of 5%. The results showed higher LDN consumption coefficients in the central-west, south and southeast regions and lower in the north and northeast. An increasing LDN dispensing was observed in 55.6% of the capitals, stationary in 44.4% and absence of decreasing coefficients. Despite the limited evidence regarding LDN pharmacotherapy and its off-label prescription, these data show that the prescription, the dispensing and the consumption have been growing in Brazil, with emphasis on the central-south regions of the country.
Palavras-chave (keywords):
ANVISA, off-label use, pharmacoepidemiology, pharmacovigilance, drug use.
Schmidt, M.G., Torres, I.L.S., Stahnke, D.N., Paniz, V.M.V.. Naltrexona em baixa dose (LDN): tendência de consumo nas capitais brasileiras e Distrito Federal, 2014 – 2020. Cien Saude Colet [periódico na internet] (2022/Set). [Citado em 10/10/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/naltrexona-em-baixa-dose-ldn-tendencia-de-consumo-nas-capitais-brasileiras-e-distrito-federal-2014-2020/18521?id=18521
