0278/2021 - O USO DE FÁRMACOS ANTICOLINÉRGICOS E FATORES ASSOCIADOS EM ADULTOS DE MEIA-IDADE E IDOSOS THE USE OF ANTICHOLINERGIC DRUGS AND ASSOCIATED FACTORS IN MIDDLE-AGED ADULTS AND THE ELDERLY
Objetivo: O objetivo deste artigo foi descrever o uso de medicamentos anticolinérgicos e possíveis fatores associados ao seu uso, em adultos de meia idade e idosos. Método: Trata-se de um estudo transversal, no qual foram incluídos todos os respondentes de 44 anos ou mais entrevistados em 2015. Foi utilizada a AnticholinergicDrugScale (ADS) e para determinação da Carga Anticolinérgica (CAC), categorizada em elevada (?3) e não-elevada (<3). Conduziu-se Regressão de Poisson com análise bruta e ajustada para investigar os fatores associados à CAC, com cálculo da Razão de Prevalência (RP) e Intervalo de Confiança 95% (IC95%). Resultados: Constatou-se prevalência de 20,7% de CAC elevada entre os respondentes, maior entre adultos de meia idade (24,1%). Após análise ajustada, mantiveram-se associadas à CAC elevada na faixa etária não idosa a polifarmácia (RP:2,356; IC95%:1,608-3,453) e uso esporádico de dois ou mais medicamentos (RP:2,535; IC95%:1,718-3,742). Nos idosos, continuaram associadas à CAC elevada o uso esporádico de dois ou mais medicamentos (RP:3,671; IC95%:2,043-6,597) e internação no último ano (RP:1,800; IC95%:1,014-3,194). Conclusão: Os resultados indicam maior prevalência de CAC entre adultos de meia-idade, polimedicados e em uso esporádico de medicamentos, o que sugere que a investigação do uso de anticolinérgicos nessa faixa etária demanda maior atenção.
Palavras-chave:
Antagonistas Colinérgicos. Efeitos Colaterais e Reações Adversas a Medicamentos. Adulto de meia-idade. Idoso.
Abstract:
Objective: The objective of this article was to describe the use of anticholinergic drugs and possible factors associated with their use, in middle-aged adults and in the elderly. Method: This is a cross-sectional study, based on data from a population-based study called VIGICARDIO. All respondents aged 44 or older interviewed in 2015 were included. Anticholinergic Drug Scale (ADS) was used to determine anticholinergic burden (ACB), categorized as significant (≥3) and non-significant (<3). Poisson regression was conducted with crude and adjusted analysis to investigate the factors associated with ACB. Results: There was a prevalence of 20.7% of significant ACB among respondents, higher among middle-aged adults (24.1%). After adjusted analysis, significant ACB (≥3) remained in the non-elderly age group with polypharmacy (PR: 2.356; 95% CI: 1.608-3.453) and sporadic use of two or more drugs (PR: 2.535; CI95%: 1.718-3.742). In the elderly, sporadic use of two or more medications (PR: 3,671; 95% CI: 2,043-6,597) and hospitalization in the last year (PR: 1,800; 95% CI: 1,014-3,194) continued to be associated with significant ACB. Conclusion: The results indicate a higher prevalence of ACB among middle-aged adults, polymedicated and in sporadic use of medications, which suggests that the investigation of the use of anticholinergicsin this age group requires greater attention.
Keywords:
Cholinergic Antagonists. Drug-Related Side Effects and Adverse Reactions.Middle Aged. Elderly.
THE USE OF ANTICHOLINERGIC DRUGS AND ASSOCIATED FACTORS IN MIDDLE-AGED ADULTS AND THE ELDERLY
Resumo (abstract):
Objective: The objective of this article was to describe the use of anticholinergic drugs and possible factors associated with their use, in middle-aged adults and in the elderly. Method: This is a cross-sectional study, based on data from a population-based study called VIGICARDIO. All respondents aged 44 or older interviewed in 2015 were included. Anticholinergic Drug Scale (ADS) was used to determine anticholinergic burden (ACB), categorized as significant (≥3) and non-significant (<3). Poisson regression was conducted with crude and adjusted analysis to investigate the factors associated with ACB. Results: There was a prevalence of 20.7% of significant ACB among respondents, higher among middle-aged adults (24.1%). After adjusted analysis, significant ACB (≥3) remained in the non-elderly age group with polypharmacy (PR: 2.356; 95% CI: 1.608-3.453) and sporadic use of two or more drugs (PR: 2.535; CI95%: 1.718-3.742). In the elderly, sporadic use of two or more medications (PR: 3,671; 95% CI: 2,043-6,597) and hospitalization in the last year (PR: 1,800; 95% CI: 1,014-3,194) continued to be associated with significant ACB. Conclusion: The results indicate a higher prevalence of ACB among middle-aged adults, polymedicated and in sporadic use of medications, which suggests that the investigation of the use of anticholinergicsin this age group requires greater attention.
Palavras-chave (keywords):
Cholinergic Antagonists. Drug-Related Side Effects and Adverse Reactions.Middle Aged. Elderly.
Pinto, E. C. P., Silva, A. M. R., Cabrera , M. A. S., Baldoni, A. O., Alfieri, D. F., de Andrade. G. F., Girotto, E.. O USO DE FÁRMACOS ANTICOLINÉRGICOS E FATORES ASSOCIADOS EM ADULTOS DE MEIA-IDADE E IDOSOS. Cien Saude Colet [periódico na internet] (2021/ago). [Citado em 24/12/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/o-uso-de-farmacos-anticolinergicos-e-fatores-associados-em-adultos-de-meiaidade-e-idosos/18177?id=18177&id=18177