0285/2022 - RISCO AMBIENTAL PROVOCADO POR RESÍDUOS DE MEDICAMENTOS NA CIDADE DO RIO DE JANEIRO DURANTE A PANDEMIA POR SARS-COVD19 ENVIRONMENTAL RISK CAUSED BY DRUG WASTE IN THE CITY OF RIO DE JANEIRO DURING THE SARS-COV19 PANDEMIC
Foi avaliada a relação entre a distribuição de medicamentos usados na Pandemia por SARS-Cov19 no município do Rio de Janeiro e o nível de risco ambiental estimado provocado por seus resíduos. A quantidade dos medicamentos distribuídos pelas unidades Atenção Primária à Saúde (APS) entre 2019 a 2021 foram coletadas. O quociente de risco (QR) correspondeu a razão entre a concentração ambiental preditiva estimada (PECest) obtida pelo consumo e excreção de cada fármaco e a sua concentração preditiva não efetiva (PNEC). Entre 2019 e 2020, o PECest da azitromicina (AZI) e da ivermectina (IVE) aumentaram entre 2019 e 2020, tendo uma queda em 2021 provavelmente devido ao desabastecimento. Já o da dexclorfeniramina (DEX) e da fluoxetina (FLU) tiveram uma queda, retornando o crescimento em 2021. Enquanto o PECest do diazepam (DIA) aumentou ao longo desses 3 anos, o etinilestradiol (EE2) reduziu possivelmente pela priorização da APS no tratamento da Covid-19. Os maiores QR foram da FLU, do EE2 e da AZI. O padrão de consumo desses medicamentos não refletiu o seu risco ambiental pois os mais consumidos possuem baixa toxicidade. Vale destacar que alguns dados podem estar subestimados devido ao incentivo que foi dado durante a pandemia para o consumo de determinados grupos de fármacos.
The relationship between the distribution of medicines used in the Pandemic by SARS-Cov19 in the municipality of Rio de Janeiro and the estimated level of environmental risk caused by their residues was evaluated. The amount of medicines distributed by Primary Health Care (PHC) units between 2019 and 2021 were collected. The risk quotient (RQ) corresponded to the ratio between the estimated predictive environmental concentration (PECest) obtained by the consumption and excretion of each drug and its non-effective predictive concentration (PNEC). Between 2019 and 2020, the PECest of azithromycin (AZI) and ivermectin (IVE) increased between 2019 and 2020, with a decrease in 2021 probably due to shortages. Dexchlorpheniramine (DEX) and fluoxetine (FLU) fell, returning to growth in 2021. While the PECest of diazepam (DIA) increased over these 3 years, ethinylestradiol (EE2) decreased possibly due to the prioritization of APS in the treatment of Covid-19. The largest QR wereFLU, EE2 and AZI. The consumption pattern of these drugs did not reflect their environmental risk because the most consumed ones have low toxicity. It is worth noting that some data may be underestimated due to the incentive given during the pandemic to the consumption of certain groups of drugs.
ENVIRONMENTAL RISK CAUSED BY DRUG WASTE IN THE CITY OF RIO DE JANEIRO DURING THE SARS-COV19 PANDEMIC
Resumo (abstract):
The relationship between the distribution of medicines used in the Pandemic by SARS-Cov19 in the municipality of Rio de Janeiro and the estimated level of environmental risk caused by their residues was evaluated. The amount of medicines distributed by Primary Health Care (PHC) units between 2019 and 2021 were collected. The risk quotient (RQ) corresponded to the ratio between the estimated predictive environmental concentration (PECest) obtained by the consumption and excretion of each drug and its non-effective predictive concentration (PNEC). Between 2019 and 2020, the PECest of azithromycin (AZI) and ivermectin (IVE) increased between 2019 and 2020, with a decrease in 2021 probably due to shortages. Dexchlorpheniramine (DEX) and fluoxetine (FLU) fell, returning to growth in 2021. While the PECest of diazepam (DIA) increased over these 3 years, ethinylestradiol (EE2) decreased possibly due to the prioritization of APS in the treatment of Covid-19. The largest QR wereFLU, EE2 and AZI. The consumption pattern of these drugs did not reflect their environmental risk because the most consumed ones have low toxicity. It is worth noting that some data may be underestimated due to the incentive given during the pandemic to the consumption of certain groups of drugs.
SOUZA, C.P.F.A., KLIGERMAN, D.C., BEZERRA, G.M., OLIVEIRA, J.L.M.. RISCO AMBIENTAL PROVOCADO POR RESÍDUOS DE MEDICAMENTOS NA CIDADE DO RIO DE JANEIRO DURANTE A PANDEMIA POR SARS-COVD19. Cien Saude Colet [periódico na internet] (2022/Out). [Citado em 10/10/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/risco-ambiental-provocado-por-residuos-de-medicamentos-na-cidade-do-rio-de-janeiro-durante-a-pandemia-por-sarscovd19/18541?id=18541
