0089/2020 - Prevalence of rheumatoid arthritis in South-America: A systematic review and meta-analysis Prevalência da artrite reumatoide na America do Sul: Revisão sistemática e meta-analise
A artrite reumatóide (AR) está entre as doenças autoimunes e inflamatórias crônicas mais prevalentes no mundo. As estimativas de prevalência variam entre regiões e fontes de informação. Assim, o objetivo deste estudo foi estabelecer uma estimativa conjunta da prevalência da AR na América do Sul por meio de uma meta-análise dos estudos epidemiológicos disponíveis. Buscas sistemáticas nas bases de dados Pubmed, Lilacs, Scielo, Scopus e Web of Science (atualizado em maio de 2019) foram seguidas por uma busca sistemática na literatura cinzenta para identificar artigos e relatórios de pesquisa originais, publicados após 2000, fornecendo dados de prevalência de AR em qualquer país da América do Sul. Foi realizada uma meta-análise da proporção de dados agrupados ponderados (prevalência de AR), com heterogeneidade entre experimentos avaliada pelo índice relativo de inconsistência. Análises de sensibilidade e de subgrupos também foram realizadas. Foram incluídos um total de 24 artigos, representando 27 estudos de base populacional. A prevalência agrupada de AR resultou em 0,48% [95% IC 0,38%-0,62%] (I2=90%) com 591.981 casos em uma população de 114.537.812 indivíduos (I2 = 99%). Brasil e Colômbia apresentaram as menores taxas de prevalência de AR (0,22% [0,05%-0,91%] e 0,24% [0,15%-0,39%], respectivamente). A prevalência da AR na população indígena foi maior (1,45% [0,88%-2,37%]), e est
Palavras-chave:
Artrite Reumatoide; Prevalência; América Latina; Acesso aos Serviços de Saúde; Metanálise como Assunto
Abstract:
Rheumatoid arthritis (RA) is among the most prevalent chronic autoimmune and inflammatory diseases worldwide. Estimates of prevalence vary among regions and sources of information. Thus, the aim of this study was to establish a pooled estimate of the RA prevalence in South America by means of a meta-analysis of the available epidemiologic studies. Systematic searches in Pubmed, Lilacs, Scielo, Scopus, and Web of Science databases (updated May 2019) were done followed by a systematic grey literature search to identify original research articles and reports, published after 2000, providing data of RA prevalence in any South American country. Proportion meta-analysis of weighted pooled (prevalence of RA) was performed, with between-trial heterogeneity assessed by the inconsistency relative index. Sensitivity analyses and sub-group analyses were also done. A total of 24 articles, representing 27 population-based studies were included. Pooled prevalence of RA resulted in 0.48% [95% CI 0.38%-0.62%] (I2=90%) with 591.981 cases in a population of 114.537.812 individuals (I2 = 99%). Brazil and Colombia presented the lowest rates of RA prevalence (0.22% [0.05%-0.91%], and 0.24% [0.15%-0.39%], respectively. RA prevalence in indigenous population was higher (1.45% [0.88%-2.37%]), and studies using COPCORD method reported also the highest rates (1.07% [0.74%-1.55%]).
Keywords:
Arthritis, Rheumatoid ; Prevalence ; Latin America ; Health Services Accessibility • Meta-Analysis as Topic
Prevalência da artrite reumatoide na America do Sul: Revisão sistemática e meta-analise
Resumo (abstract):
Rheumatoid arthritis (RA) is among the most prevalent chronic autoimmune and inflammatory diseases worldwide. Estimates of prevalence vary among regions and sources of information. Thus, the aim of this study was to establish a pooled estimate of the RA prevalence in South America by means of a meta-analysis of the available epidemiologic studies. Systematic searches in Pubmed, Lilacs, Scielo, Scopus, and Web of Science databases (updated May 2019) were done followed by a systematic grey literature search to identify original research articles and reports, published after 2000, providing data of RA prevalence in any South American country. Proportion meta-analysis of weighted pooled (prevalence of RA) was performed, with between-trial heterogeneity assessed by the inconsistency relative index. Sensitivity analyses and sub-group analyses were also done. A total of 24 articles, representing 27 population-based studies were included. Pooled prevalence of RA resulted in 0.48% [95% CI 0.38%-0.62%] (I2=90%) with 591.981 cases in a population of 114.537.812 individuals (I2 = 99%). Brazil and Colombia presented the lowest rates of RA prevalence (0.22% [0.05%-0.91%], and 0.24% [0.15%-0.39%], respectively. RA prevalence in indigenous population was higher (1.45% [0.88%-2.37%]), and studies using COPCORD method reported also the highest rates (1.07% [0.74%-1.55%]).
Palavras-chave (keywords):
Arthritis, Rheumatoid ; Prevalence ; Latin America ; Health Services Accessibility • Meta-Analysis as Topic
Germano, J.L, Reis-Pardal, J, Tonin, F.S, Pontarolo, R., Melchiors, A.M., Fernandez-Llimos, F. Prevalence of rheumatoid arthritis in South-America: A systematic review and meta-analysis. Cien Saude Colet [periódico na internet] (2020/mai). [Citado em 23/12/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/prevalence-of-rheumatoid-arthritis-in-southamerica-a-systematic-review-and-metaanalysis/17571?id=17571
