0010/2022 - A medida da amplitude da distribuição do tamanho dos eritrócitos está associada ao risco cardiovascular em adultos
Red cell distribution width is associated with cardiovascular risk in adults
Publicado
Author:
• Natane Moreira de Carvalho - de Carvalho, N. M. - <natanecarvalho@gmail.com>ORCID: https://orcid.org/0000-0003-1083-7640
Co-author(s):
• Chams Bicalho Maluf - Maluf, C. B. - <chamsbm12@gmail.com>ORCID: https://orcid.org/0000-0002-3690-2554
• Douglas Roberto Mesquita Azevedo - Azevedo, D. R. M. - <douglasrm.azevedo@gmail.com>
ORCID: https://orcid.org/0000-0001-9741-8662
• Rodrigo Citton P. dos Reis - dos Reis, R. C. P. - <rodrigocpdosreis@gmail.com>
ORCID: https://orcid.org/0000-0003-1766-0964
• Cristina Dickie de Castilhos - de Castilhos, C. D. - <ccdickie@gmail.com>
ORCID: https://orcid.org/0000-0001-5986-7942
• Sandhi Maria Barreto - Barreto, S. M - <sandhi.barreto@gmail.com>
ORCID: https://orcid.org/0000-0001-7383-7811
• Pedro Guatimosim Vidigal - Vidigal, P. G. - <pedrovidigal@ufmg.br>
ORCID: https://orcid.org/0000-0001-8035-1350
Abstract:
Background: Red cell distribution width (RDW) is a measure of erythrocyte size variability. Recent studies have shown that RDW is a predictive, and prognostic marker of mortality and cardiovascular (CVD) events in the general population and in CVD patients. This study aimed to investigate the association between RDW and CVD risk in a large sample of adults.Methods: A subsample of CVDfree participants of the ELSA–Brasil cohort were included (n=4481). In the cross-sectional approach, multiple regression analysis was used to investigate the association between RDW and the Framingham Risk Score (FRS). Linear mixed effect model evaluated whether baseline RDW predicted changes in CVD risk after about four-year follow up.
Results: Cross-sectional analysis showed that RDW was independently associated with FRS, participants in the fourth-quartile of RDW distribution had a 29% higher FRS than those in the first-quartile RDW (p < 0.001). A longitudinal analysis revealed that RDW remained associated with increased FRS.
Conclusions: In this large cohort of adult Brazilians, RDW was independently associated with increased CVD risk, as measured by the FRS, both at baseline and after four-year follow-up. However, RDW did not predict change in CVD risk in this short-term follow up.
