Author:

• Elizabeth de Paula Franco - Franco, E. de P. - <nutrielizabethdepaula@gmail.com>
ORCID: https://orcid.org/0000-0001-6287-5142

Co-author(s):

• Daniele Marano Rocha - Rocha, D.M - <danielemarano@yahoo.com.br>
ORCID: https://orcid.org/0000-0001-6985-941X
• Silvana Granado Nogueira da Gama - Gama, S.G.N - <silvana.granado@gmail.com>
ORCID: https://orcid.org/0000-0002-9200-0387
• Martinelli, Katrini Guidolini - Guidolini, M. K. - <katrigm@gmail.com>
ORCID: https://orcid.org/0000-0003-0894-3241

Abstract:

: To evaluate the causal effect of hypertensive syndromes of pregnancy on prematurity. Data were obtainedthe nationwide study “Born in Brazil” with 23.894 women. Hypertensive syndromes comprised the synthesis of positive responses to any of the questions relating to increased blood pressure contained in the questionnaires completed with datathe hospital record and prenatal card. The outcome was early and late preterm birth. The confounding variables were indicated in the directed acyclic graph, and the causal effect was estimated by the propensity score. Of the 20.494 postpartum women evaluated, 2.369 had a diagnosis of hypertensive syndromes, and among these, 5.8% were early premature births and 13.5% were late. After weighting, women with hypertensive syndromes had a 2.74 chance of having an early preterm birth (ORadj:2.74; 95% CI:2.12-3.54) and a 2.40 chance of having a late preterm birth (ORadj:2.40; 95% CI:1.86-3.08). The causal effect of hypertensive syndromes on prematurity reaffirmed their role in causing an increase in premature births, reinforcing the importance of controlling syndromes during prenatal care.

Keywords:

Hypertension Pregnancy-Induced. Early prematurity. Late prematurity. Directed acyclic graph. Propensity score.

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