Author:

• Angelo Azevedo - Azevedo, Angelo - None Provided - <angelodeveza@gmail.com>

Co-author(s):

• Aurigena Antunes De Araujo - DE ARAUJO, AURIGENA ANTUNES - UFRN, DEPARTAMENTO DE BIOFISICA E FARMACOLOGIA - <aurigena@ufrnet.br>
• MARIA ANGELA FERNANDES FERREIRA - FERREIRA MAF - NATAL, RN - Universidade Federal do Rio Grande do Norte, Odontologia - <angelaf@ufrnet.br>
ORCID: https://orcid.org/0000-0002-6142-948X

Thematic Area:

Assistência Farmacêutica

Abstract:

ABSTRACT

Objective: To determine the distribution and frequency of intake of benzodiazepine anxiolytics, as well as evaluating the correlation between intake and demographic, epidemiological, economic and social characteristics. Methodology: ecological study as sampling units the 27 state capitals. Data collection was performed through the bank of ANVISA for the dispensation of Alprazolam, Bromazepam, Clonazepam, Diazepam and Lorazepam in the period 2010-2012, the 2010 Demographic Census (IBGE), DATASUS and Research Medical Demography. Descriptive statistical analysis and multiple linear regression analyzes were performed for data analysis. Results: The northern region has the lowest average capital with intake of these products and the southeast higher. The average intake for the population of all capital was 3.60 DHD. The Alprazolam is the most dispensed by pharmacies and private drugstores with average 2.00 DHD for Brazilian capital. A multiple linear regression analysis showed that 76% of the variance in intake was explained by variation in population density (β = 0.310 p = 0.045) and percentage of physicians (β = 0.507 p = 0.016). Conclusion: Intake of anxiolytics short half-life has been growing over the years, mainly in the cities of greater population density and concentration of physicians.

Keywords:

Benzodiazepine-anxiolyticsIntakeState capitalsSociodemographic

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