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0349/2018 - Lipodistrophic syndrome of HIV and its associated factors: A study in a university hospital.
Síndrome lipodistrófica do HIV e seus fatores associados: Um estudo Em um hospital universitário.

Author:

• Lídia Laís Gomes - Silva, L.L.G - <lidialaisgs@gmail.com>
ORCID: http://orcid.org/0000-0001-7673-7680

Co-author(s):

• Eryka Maria dos Santos - Santos, E.M - <erykasantos.nutri@gmail.com>
ORCID: https://orcid.org/0000-0002-0317-7456
• Luciana Caroline Paulino do Nascimento - Nascimento, L.C.P - <lucianacpnascimento@hotmail.com>
ORCID: https://orcid.org/0000-0002-7447-9670
• Mikaella Cavalcanti - Cavalcanti, M - <cfcmikaella@gmail.com>
ORCID: https://orcid.org/0000-0003-2426-1582
• Ilma Kruze Grande de Arruda - Arruda, I. K. G - <ilma.arruda@ufpe.br>
ORCID: https://orcid.org/0000-0002-7142-1967
• Marcella Campos Lima - Lima, M.C - <cellacamposlima@gmail.com>
ORCID: https://orcid.org/0000-0001-9226-1387
• Poliana Coelho Cabral - Cabral, P. C. - <poliana.cabral@ufpe.br>
ORCID: https://orcid.org/0000-0002-2709-4823


Abstract:

Introduction: The use of antiretroviral drugs has increased the survival of HIV patients, but it can lead to side effects, such as lipodystrophic syndrome. Objective: To identify the frequency of lipodystrophic syndrome and its associated factors in patients with HIV using antiretroviral therapy. Methodology: A cross-sectional study with HIV patients, accompanied by outpatients. The syndrome was evaluated by the association of two parameters: peripheral weight loss through the lipodystrophy severity scale and central fat accumulation, measured by the hip waist ratio. To identify the variables associated was performed Poisson regression analysis. . Results: Of the 104 patients evaluated, 27.9% presented the syndrome. After adjustment, the female sex (PRadjusted = 2,16 CI95% 1,43-3,39), being overweight (PRadjusted = 2,23 CI95% 1,35-2,65) and a longer time of use of the antiretrovirals (PRadjusted = 1,64 CI95% 1,16-2,78), remained positively associated with the syndrome. On the other hand, it was observed negative association with CD4 count  350 (PRadjusted=0,39 CI95%0,10-0,97). Conclusion: The high prevalence of the syndrome and its association with specific groups reinforce the need for adequate follow-up and early identification to intervene in modifiable factors.

Keywords:

Lipodystrophy; AIDS; Anthropometry; Antiretroviral Therapy

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Silva, L.L.G, Santos, E.M, Nascimento, L.C.P, Cavalcanti, M, Arruda, I. K. G, Lima, M.C, Cabral, P. C.. Lipodistrophic syndrome of HIV and its associated factors: A study in a university hospital.. Cien Saude Colet [periódico na internet] (2018/Jul). [Citado em 21/01/2025]. Está disponível em: http://cienciaesaudecoletiva.com.br/en/articles/lipodistrophic-syndrome-of-hiv-and-its-associated-factors-a-study-in-a-university-hospital/16882?id=16882



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