Author:

• Daniel Marques Mota - Mota, D.M - BRASÍLIA - Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Epidemiologia - <dmarques2003@yahoo.com.br>
ORCID: http://orcid.org/0000-0003-4156-0138

Co-author(s):

• Álvaro Vigo - Vigo, A - Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Epidemiologia - <alvaro.vigo@ufrgs.br>
ORCID: http://orcid.org/0000-0002-5797-9470
• Ricardo de Souza Kuchenbecker - Kuchenbecker, Ricardo de Souza - Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Epidemiologia - <rkuchenbecker@hcpa.edu.br>

Thematic Area:

Assistência Farmacêutica

Abstract:

To propose a reference list of codes of the International Classification of Diseases and Related Health Problems (ICD-10) for the surveillance of adverse drug reactions and drug poisoning, called adverse events. The preparation of reference list occurred in four phases: one related the definition of the codes, validation and two characterization of the list. Associations between variables were evaluated using the Pearson‘s chi-squared test and multiple correspondence analysis. There were identified 691 codes related to adverse drug reactions (52.1%) and drug poisoning (47.9%). A total of 687 (99.4%) and 511 (73.9%) codes were validated in 1st and 2nd validation, respectively. There were statistically significant differences (p <0.05) between adverse reactions and drug poisoning in the variables used to characterize the reference list. The association between drug and hospital admission and death was statistically significant when stratified by type of adverse event (p <0.001). In multiple correspondence analysis identified three grouping of codes where there are associations between categories of response assessed. The reference list can be a useful tool in pharmacovigilance actions in Brazil.

Keywords:

International Classification of DiseasesDrug-Related Side Effects and Adverse ReactionsPoisoning

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