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0348/2017 - Risk factors for cardiovascular disease in HIV/AIDS patients treated with highly active antiretroviral therapy (HAART) in the central-southern region of the state of Paraná – Brazil.

Author:

• Erildo Vicente Muller - Muller, E. V. - <erildomuller@hotmail.com>
ORCID: https://orcid.org/0000-0003-4643-056X

Co-author(s):

• Suely Godoy Agostinho Gimeno - Gimeno S. G. A. - <sgag@uol.com.br>
ORCID: https://orcid.org/0000-0002-3341-7676


Abstract:

The aim of this study was to describe metabolic changes in HIV/AIDS patients according to the treatment regimen. It was a retrospective cohort conducted2012 to 2014. Researchers surveyed clinical variables and treatment regimen of 538 individuals. They used measures of central tendency and marginal logistic regression to determine the influence of the treatment regimen on clinical variables over time; survival was estimated using Kaplan-Meier curves. 56.2% of patients were male, 82.2% white, 33.8% had 4 to 7 years of study, 49.2% were married, 98.5% had sexual transmission, and 89.0% were heterosexuals. During the study period, 24.4% had hypertension, 18.2% changed cholesterol, 39.7% low HDL, 51.3% high triglycerides and 33.3% hyperglycemia. Treatment regimens with nucleotide reverse transcriptase inhibitors associated with protease inhibitors, and the association of different classes of antiretrovirals have been associated with greater lipid changes. Higher metabolic changes were observed in patients with longer treatment time. It is concluded that preventive measures, as well as early treatment, can contribute to minimize the risks of developing cardiovascular diseases.

Keywords:

Acquired immunodeficiency syndrome; Survival, Highly active antiretroviral therapy, Cardiovascular risk factor.

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Muller, E. V., Gimeno S. G. A.. Risk factors for cardiovascular disease in HIV/AIDS patients treated with highly active antiretroviral therapy (HAART) in the central-southern region of the state of Paraná – Brazil.. Cien Saude Colet [periódico na internet] (2017/Sep). [Citado em 22/01/2025]. Está disponível em: http://cienciaesaudecoletiva.com.br/en/articles/risk-factors-for-cardiovascular-disease-in-hivaids-patients-treated-with-highly-active-antiretroviral-therapy-haart-in-the-centralsouthern-region-of-the-state-of-parana-brazil/16400?id=16400&id=16400



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