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0278/2021 - THE USE OF ANTICHOLINERGIC DRUGS AND ASSOCIATED FACTORS IN MIDDLE-AGED ADULTS AND THE ELDERLY
O USO DE FÁRMACOS ANTICOLINÉRGICOS E FATORES ASSOCIADOS EM ADULTOS DE MEIA-IDADE E IDOSOS

Author:

• Eliz Cassieli Pereira Pinto - Pinto, E. C. P. - <cassielipinto2@gmail.com>
ORCID: https://orcid.org/0000-0002-6089-403X

Co-author(s):

• Ana Maria Rigo Silva - Silva, A. M. R. - <arigosilva@gmail.com>
ORCID: https://orcid.org/0000-0002-9527-4914
• Marcos Aparecido Sarria Cabrera - Cabrera , M. A. S. - <marcoscabrera@uol.com.br>
ORCID: https://orcid.org/0000-0001-9786-9674
• André de Oliveira Baldoni - Baldoni, A. O. - <andrebaldoni@ufsj.edu.br, andrebaldoni@yahoo.com.br>
ORCID: https://orcid.org/0000-0001-6379-0415
• Daniela Frizon Alfieri - Alfieri, D. F. - <frizon.alfieri@gmail.com>
ORCID: https://orcid.org/0000-0002-0217-9329
• Giovana Frazon de Andrade - de Andrade. G. F. - <giovanafrazon@hotmail.com>
ORCID: https://orcid.org/0000-0002-9120-0600
• Edmarlon Girotto - Girotto, E. - <edmarlon78@gmail.com>
ORCID: https://orcid.org/0000-0001-9345-3348


Abstract:

Objective: The objective of this article was to describe the use of anticholinergic drugs and possible factors associated with their use, in middle-aged adults and in the elderly. Method: This is a cross-sectional study, based on data from a population-based study called VIGICARDIO. All respondents aged 44 or older interviewed in 2015 were included. Anticholinergic Drug Scale (ADS) was used to determine anticholinergic burden (ACB), categorized as significant (≥3) and non-significant (<3). Poisson regression was conducted with crude and adjusted analysis to investigate the factors associated with ACB. Results: There was a prevalence of 20.7% of significant ACB among respondents, higher among middle-aged adults (24.1%). After adjusted analysis, significant ACB (≥3) remained in the non-elderly age group with polypharmacy (PR: 2.356; 95% CI: 1.608-3.453) and sporadic use of two or more drugs (PR: 2.535; CI95%: 1.718-3.742). In the elderly, sporadic use of two or more medications (PR: 3,671; 95% CI: 2,043-6,597) and hospitalization in the last year (PR: 1,800; 95% CI: 1,014-3,194) continued to be associated with significant ACB. Conclusion: The results indicate a higher prevalence of ACB among middle-aged adults, polymedicated and in sporadic use of medications, which suggests that the investigation of the use of anticholinergicsin this age group requires greater attention.

Keywords:

Cholinergic Antagonists. Drug-Related Side Effects and Adverse Reactions.Middle Aged. Elderly.

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Pinto, E. C. P., Silva, A. M. R., Cabrera , M. A. S., Baldoni, A. O., Alfieri, D. F., de Andrade. G. F., Girotto, E.. THE USE OF ANTICHOLINERGIC DRUGS AND ASSOCIATED FACTORS IN MIDDLE-AGED ADULTS AND THE ELDERLY. Cien Saude Colet [periódico na internet] (2021/Aug). [Citado em 27/09/2024]. Está disponível em: http://cienciaesaudecoletiva.com.br/en/articles/the-use-of-anticholinergic-drugs-and-associated-factors-in-middleaged-adults-and-the-elderly/18177?id=18177



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