• Fernando Antonio de Almeida - Almeida, F.A. - Sorocaba, SP - Faculdade de Ciências Médicas e da Saúde da PUC/SP - Medicine Rua Joubert Wey 290 Sorocaba, Sorocaba, SP 18030230 Brazil - <faalmeida@globo.com>
Coautor(es):
• André Luz Bertoco - Bertoco, André Luz - Faculdade de Ciências Médicas e da Saúde da PUC/SP - <faalmeida@globo.com>
• Maria Valeria Pavan - Pavan,Maria Valeria - Faculdade de Ciências Médicas e da Saúde da PUC/SP - <faalmeida@globo.com>
• Guilherme Siqueira Vasconcelos - Vasconcelos, Guilherme Siqueira - Faculdade de Ciências Médicas e da Saúde da PUC/SP - <faalmeida@globo.com>
• Eder Augusto Bernardo - Bernardo, Eder Augusto - Faculdade de Ciências Médicas e da Saúde da PUC/SP - <faalmeida@globo.com>
• Marcelo Mai Jurado - Jurado,Marcelo Mai - Faculdade de Ciências Médicas e da Saúde da PUC/SP - <faalmeida@globo.com>
• Guiliano Serafino Ciambele - Ciambele,Guiliano Serafino - Faculdade de Ciências Médicas e da Saúde da PUC/SP - <faalmeida@globo.com>
• Reinaldo José Gianini - Gianini,Reinaldo José - Faculdade de Ciências Médicas e da Saúde da PUC/SP - <faalmeida@globo.com>
Área Temática:
Avaliação de Serviços de Saúde
Resumo:
No Brasil a hipertensão e o diabetes mellitus tipo 2 são responsáveis por 60% dos casos de doença renal crônica terminal em terapia renal substitutiva. Estudos americanos identificaram agregação familiar da doença renal crônica, predominante em afro-descendentes. Um único estudo brasileiro observou agregação familiar entre portadores de doença renal crônica quando comparados a indivíduos internados com função renal normal. Objetivo: avaliar se existe agregação familiar da doença renal crônica em familiares de indivíduos em terapia renal substitutiva causada por hipertensão e/ou diabetes mellitus. Métodos: estudo caso-controle tendo como casos 336 pacientes em terapia renal substitutiva portadores de diabetes mellitus ou hipertensão há pelo menos 5 anos e controles amostra pareada de indivíduos com hipertensão ou diabetes mellitus e função renal normal (n=389). Resultados: Os indivíduos em terapia renal substitutiva (casos) apresentaram razão de chance de 2,35 (IC95% 1,42–3,89; p<0,001) versus controles de terem familiares com doença renal crônica terminal, independente da raça ou doença de base. Conclusão: Existe agregação familiar da doença renal crônica na amostra estudada e esta predisposição independe da raça e da doença de base (hipertensão ou diabetes mellitus).
In Brazil hypertension and type 2 diabetes mellitus are responsible for 60 % of cases of end-stage renal disease on renal replacement therapy. In United States studies have identified familial aggregation of chronic kidney disease, predominantly in African-Americans. One Brazilian study observed familial aggregation among patients with chronic kidney disease compared to hospitalized patients with normal renal function. Objective: To assess whether there is familial aggregation of chronic kidney disease in relatives of individuals on renal replacement therapy caused by hypertension and/or diabetes mellitus. Methods: A case-control study with 336 patients in renal replacement therapy with diabetes mellitus or hypertension for at least 5 years (cases) and as control a matched sample of individuals with hypertension or diabetes mellitus and normal renal function (n=389). Results: Individuals in renal replacement therapy (cases) had an odds ratio of 2.35 (95% CI 1.42-3.89, p < 0.001) versus controls in having relatives with chronic renal disease, independent of race or causative illness. Conclusion: There is familial aggregation of chronic kidney disease in the sample studied, and this predisposition is independent of race and underlying disease (hypertension or diabetes mellitus)
Agregação Familiar da Doença Renal Crônica Secundária à Hipertensão Arterial ou Diabetes Mellitus. Estudo Caso-Controle
Resumo (abstract):
In Brazil hypertension and type 2 diabetes mellitus are responsible for 60 % of cases of end-stage renal disease on renal replacement therapy. In United States studies have identified familial aggregation of chronic kidney disease, predominantly in African-Americans. One Brazilian study observed familial aggregation among patients with chronic kidney disease compared to hospitalized patients with normal renal function. Objective: To assess whether there is familial aggregation of chronic kidney disease in relatives of individuals on renal replacement therapy caused by hypertension and/or diabetes mellitus. Methods: A case-control study with 336 patients in renal replacement therapy with diabetes mellitus or hypertension for at least 5 years (cases) and as control a matched sample of individuals with hypertension or diabetes mellitus and normal renal function (n=389). Results: Individuals in renal replacement therapy (cases) had an odds ratio of 2.35 (95% CI 1.42-3.89, p < 0.001) versus controls in having relatives with chronic renal disease, independent of race or causative illness. Conclusion: There is familial aggregation of chronic kidney disease in the sample studied, and this predisposition is independent of race and underlying disease (hypertension or diabetes mellitus)
