0139/2016 - Prevalência de hemoglobinas variantes em comunidades quilombolas no estado do Piauí. Prevalence of variants hemoglobins in quilombolas communities in Piauí state .
• BOLIVAR PONCIANO GOULART DE LIMA DAMASCENO - DAMASCENO, BOLIVAR PONCIANO GOULART DE LIMA - UEPB, DF - <bolivarpgld@hotmail.com>
• MARILDA DE SOUZA GONÇALVEZ - GONÇALVES, MARILDA DE SOUZA - UFBA, DCF - <mari@bahia.fiocruz.br>
Área Temática:
Epidemiologia
Resumo:
As hemoglobinas variantes (Hb) decorrem de mutações nos genes da globina. As variantes estruturais mais frequentes são HbS, HbC, HbD e HbE. O gene da hemoglobina S tem frequência elevada na América e Brasil é maior no Sudeste e Nordeste. Objetivos: investigar a presença de hemoglobinas variantes em 15 comunidades quilombolas do estado do Piauí. Método: Foram analisadas 1.239 amostras, as hemoglobinas foram triadas pela cromatografia líquida de alta eficiência (HPLC). Aplicou-se questionário referente a gênero, etnia e consanguinidade das populações. Resultados: Das 1.239 amostras 5,4% apresentaram o traço falciforme AS, a doença falciforme SS e SC foi 0,8%, hemoglobinas AC (0,2%), AD (0,6%) e DD (0,1%). Das 1.069 pessoas negras 84 apresentaram alteração das hemoglobinas, destas 34 pessoas eram do sexo masculino, 53 do sexo feminino. Ocorreu a presença de 13 casamentos consanguíneos dentre as 84 alterações das hemoglobinas. Conclusão: O estudo das hemoglobinas variantes em 15 comunidades remanescentes de quilombos no estado do Piauí contribui para sua educação em saúde frente aos aspectos da herança genética das hemoglobinas, relevante questão de saúde pública, proporcionando subsídios para a implantação do Programa Estadual da Doença Falciforme no estado do Piauí.
Palavras-chave:
Doença falciformetraço falciformesaúde da população negra
Abstract:
Introduction: The variant hemoglobins (Hb) mostly result from mutations in globin gene, with amino acid substitution in the polypeptide chain. Among the most common structural variants are the HbS, HbC, HbD and HbE. The hemoglobin S gene is a high frequency gene across America and Brazil is more frequent in the Southeast and Northeast. Objectives: To investigate the presence of hemoglobin variants in 15 quilombo communities of Piaui state. Method: The sample was of 1,239 people and hemoglobin were screened by high-performance liquid chromatography (HPLC). Questionnaire was applied related to gender, ethnicity and inbreeding populations. Results: Of the 1,239 samples analyzed 5.4% had sickle cell trait AS, while sickle cell anemia SS and SC showed a rate of 0.8%, were also identified AC hemoglobin (0.2%), AD (0.6%) and DD (0.1%). Of the 1,069 black people declared 84 showed abnormalities of hemoglobin, these 34 people were male while 53 were female. There was the presence of 13 consanguineous marriages among the 84 changes in hemoglobin. Conclusion: The study of hemoglobin variants in 15 former quilombo communities in the state of Piaui contributes to their education in health in the aspects of genetic inheritance of hemoglobin, relevant public health issue, providing subsidies for the implementation of the State Program of Sickle Cell Disease in State of Piaui.
Keywords:
Sickle cell diseasesickle cell traithealth of the black population
Prevalence of variants hemoglobins in quilombolas communities in Piauí state .
Resumo (abstract):
Introduction: The variant hemoglobins (Hb) mostly result from mutations in globin gene, with amino acid substitution in the polypeptide chain. Among the most common structural variants are the HbS, HbC, HbD and HbE. The hemoglobin S gene is a high frequency gene across America and Brazil is more frequent in the Southeast and Northeast. Objectives: To investigate the presence of hemoglobin variants in 15 quilombo communities of Piaui state. Method: The sample was of 1,239 people and hemoglobin were screened by high-performance liquid chromatography (HPLC). Questionnaire was applied related to gender, ethnicity and inbreeding populations. Results: Of the 1,239 samples analyzed 5.4% had sickle cell trait AS, while sickle cell anemia SS and SC showed a rate of 0.8%, were also identified AC hemoglobin (0.2%), AD (0.6%) and DD (0.1%). Of the 1,069 black people declared 84 showed abnormalities of hemoglobin, these 34 people were male while 53 were female. There was the presence of 13 consanguineous marriages among the 84 changes in hemoglobin. Conclusion: The study of hemoglobin variants in 15 former quilombo communities in the state of Piaui contributes to their education in health in the aspects of genetic inheritance of hemoglobin, relevant public health issue, providing subsidies for the implementation of the State Program of Sickle Cell Disease in State of Piaui.
Palavras-chave (keywords):
Sickle cell diseasesickle cell traithealth of the black population
Soares, Leonardo Ferreira, LIMA, ELEONIDAS MOURA, SILVA, JOSÉ ALEXSANDRO DA, Fernandes, Suenia Soares, Silva, Keyla Malba da costa, Lins, Sarah Pereira, DAMASCENO, BOLIVAR PONCIANO GOULART DE LIMA, GONÇALVES, MARILDA DE SOUZA. Prevalência de hemoglobinas variantes em comunidades quilombolas no estado do Piauí.. Cien Saude Colet [periódico na internet] (2016/mar). [Citado em 23/12/2024].
Está disponível em: http://cienciaesaudecoletiva.com.br/artigos/prevalencia-de-hemoglobinas-variantes-em-comunidades-quilombolas-no-estado-do-piaui/15563?id=15563&id=15563